Drug General Information
Drug ID
D00XWB
Former ID
DIB001382
Drug Name
F-15845
Drug Type
Small molecular drug
Indication Angina pectoris [ICD9: 413; ICD10:I20] Phase 1 [548229]
Company
Pierre Fabre SA
Structure
Download
2D MOL

3D MOL

Formula
C20H26BrNO2S2
CAS Number
CAS 470454-73-0
PubChem Compound ID
Target and Pathway
Target(s) Sodium channel protein type 5 subunit alpha Target Info Inhibitor [531108], [532635]
KEGG Pathway Adrenergic signaling in cardiomyocytes
PathWhiz Pathway Muscle/Heart Contraction
Reactome Interaction between L1 and Ankyrins
WikiPathways SIDS Susceptibility Pathways
Cardiac Progenitor Differentiation
References
Ref 548229Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800023448)
Ref 531108Selective inhibition of persistent sodium current by F 15845 prevents ischaemia-induced arrhythmias. Br J Pharmacol. 2010 Sep;161(1):79-91.
Ref 532635A rare loss-of-function SCN5A variant is associated with lidocaine-induced ventricular fibrillation. Pharmacogenomics J. 2014 Aug;14(4):372-5.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.