Drug Information

Drug General Information
Drug ID
D0G4CF
Former ID
DNC008425
Drug Name
CVT-6883
Drug Type
Small molecular drug
Indication Asthma [ICD10:J45] Phase 1 [532020], [540984]
Structure
Download
2D MOL

3D MOL
Formula
C21H21F3N6O2
InChI
InChI=1S/C21H21F3N6O2/c1-3-8-30-19(31)16-18(29(4-2)20(30)32)27-17(26-16)14-10-25-28(12-14)11-13-6-5-7-15(9-13)21(22,23)24/h5-7,9-10,12H,3-4,8,11H2,1-2H3,(H,26,27)
InChIKey
KOYXXLLNCXWUNF-UHFFFAOYSA-N
PubChem Compound ID
11270783
PubChem Substance ID
16356958, 16884502, 23444452, 42350268, 77258079, 103567106, 103905523, 104056367, 134345630, 139362650, 172650386, 174007167, 178102249, 198957650, 226589516, 241141414, 241377144, 244488592, 249691275, 252158305, 252450738
Target and Pathway
Target(s) Adenosine A2b receptor Target Info Modulator [532020]
KEGG Pathway Rap1 signaling pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Alcoholism
NetPath Pathway TGF_beta_Receptor Signaling Pathway
TCR Signaling Pathway
Pathway Interaction Database C-MYB transcription factor network
PathWhiz Pathway Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
Reactome Adenosine P1 receptors
G alpha (s) signalling events
Surfactant metabolism
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 532020GS-6201, a selective blocker of the A2B adenosine receptor, attenuates cardiac remodeling after acute myocardial infarction in the mouse. J Pharmacol Exp Ther. 2012 Dec;343(3):587-95.
Ref 540984(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5615).
Ref 532020GS-6201, a selective blocker of the A2B adenosine receptor, attenuates cardiac remodeling after acute myocardial infarction in the mouse. J Pharmacol Exp Ther. 2012 Dec;343(3):587-95.

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