Drug Information

Drug General Information
Drug ID
D02SVQ
Former ID
DIB004458
Drug Name
HBI-3000
Synonyms
Sulcardine; Multi-ion channel blocker (oral, arrhythmia), SIMM; Multi-ion channel blocker (oral/iv, arrhythmia), HUYA
Indication Heart arrhythmia [ICD10:I47-I49] Phase 2 [523241]
Company
Shanghai Institute of Materia Medica of the Chinese Academy of Sciences
Structure
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2D MOL

3D MOL
Canonical SMILES
C1CN(CC1)Cc1cc(cc(c1O)CN1CCCC1)CNS(=O)(=O)c1ccc(cc1)OC
Target and Pathway
Target(s) Calcium channel Target Info Blocker [531239]
Potassium channel Target Info Blocker [531239]
References
Ref 523241ClinicalTrials.gov (NCT01235156) Efficacy and Safety of Sulcardine Sulfate Tablets in Patients With Premature Ventricular Contractions. U.S. National Institutes of Health.
Ref 531239Electrophysiological properties of HBI-3000: a new antiarrhythmic agent with multiple-channel blocking properties in human ventricular myocytes. J Cardiovasc Pharmacol. 2011 Jan;57(1):79-85.

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