TTD | Drug: D0LI1C

Drug General Information
Drug ID	D0LI1C
Former ID	DNC011182
Drug Name	NITD609
Drug Type	Small molecular drug
Indication	Malaria [ICD10:B54]		Phase 2	[549327]
Structure		Download 2D MOL 3D MOL
Formula	C19H14Cl2FN3O
Canonical SMILES	CC1CC2=C(C3(N1)C4=C(C=CC(=C4)Cl)NC3=O)NC5=CC(=C(C=C25)F<br />)Cl
InChI	1S/C19H14Cl2FN3O/c1-8-4-11-10-6-14(22)13(21)7-16(10)23-17(11)19(25-8)12-5-9(20)2-3-15(12)24-18(19)26/h2-3,5-8,23,25H,4H2,1H3,(H,24,26)/t8-,19+/m0/s1
InChIKey	CKLPLPZSUQEDRT-WPCRTTGESA-N
PubChem Compound ID	44469321
Target and Pathway
Target(s)	Adenosine A3 receptor	Target Info	Inhibitor	[531146]
Target(s)	Potassium voltage-gated channel subfamily H member 2	Target Info	Inhibitor	[531146]
PathWhiz Pathway	Muscle/Heart Contraction
Reactome	Adenosine P1 receptors
Reactome	G alpha (i) signalling eventsR-HSA-1296072:Voltage gated Potassium channels
WikiPathways	Nucleotide GPCRs
	GPCRs, Class A Rhodopsin-like
	GPCRs, OtherWP706:SIDS Susceptibility Pathways
	Hematopoietic Stem Cell Differentiation
	Potassium Channels
References
Ref 549327	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800035252)
Ref 531146	Science. 2010 Sep 3;329(5996):1175-80.Spiroindolones, a potent compound class for the treatment of malaria.

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Drug Information