Drug Information

Drug General Information
Drug ID
D0DT1R
Former ID
DNC001462
Drug Name
Triapine
Drug Type
Small molecular drug
Indication Nerve injury [ICD10:T14.4] Phase 2 [530131]
Structure
Download
2D MOL

3D MOL
Formula
C7H9N5S
Canonical SMILES
C1=CC(=C(N=C1)C=NNC(=S)N)N
InChI
1S/C7H9N5S/c8-5-2-1-3-10-6(5)4-11-12-7(9)13/h1-4H,8H2,(H3,9,12,13)/b11-4+
InChIKey
XMYKNCNAZKMVQN-NYYWCZLTSA-N
CAS Number
CAS 236392-56-6
PubChem Compound ID
9571836
PubChem Substance ID
510133, 809489, 15322354, 23997063, 44710003, 49977503, 50630633, 53790121, 57372948, 103522243, 126680898, 132556347, 134340642, 135082505, 135156086, 137132427, 141862348, 162219716, 163417372, 164192051, 172836320, 172913921, 177218153, 184024310, 184024330, 184525729, 184525750, 184525771, 198986376, 210274660, 210280291, 223665245, 225380728, 226416462, 241035630, 249858431, 251971019, 252066194, 252499503, 252554240
Target and Pathway
Target(s) Ribonucleoside-diphosphatereductase subunit M2 Target Info Modulator [530131]
BioCyc Pathway Pyrimidine deoxyribonucleotides biosynthesis from CTP
Pyrimidine deoxyribonucleotides de novo biosynthesis
Guanosine nucleotides de novo biosynthesis
Superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis
Superpathway of purine nucleotide salvage
Purine nucleotides de novo biosynthesis
Adenosine deoxyribonucleotides de novo biosynthesis
Guanosine deoxyribonucleotides de novo biosynthesis
KEGG Pathway Purine metabolism
Pyrimidine metabolism
Glutathione metabolism
Metabolic pathways
p53 signaling pathway
NetPath Pathway EGFR1 Signaling Pathway
PANTHER Pathway p53 pathway
De novo purine biosynthesis
De novo pyrimidine deoxyribonucleotide biosynthesis
Pathway Interaction Database E2F transcription factor network
PathWhiz Pathway Purine Metabolism
Pyrimidine Metabolism
Reactome E2F mediated regulation of DNA replication
G1/S-Specific Transcription
WikiPathways Nucleotide Metabolism
Retinoblastoma (RB) in Cancer
Metabolism of nucleotides
Fluoropyrimidine Activity
References
Ref 530131PAN-811 inhibits oxidative stress-induced cell death of human Alzheimer's disease-derived and age-matched olfactory neuroepithelial cells via suppression of intracellular reactive oxygen species. J Alzheimers Dis. 2009;17(3):611-9.
Ref 530131PAN-811 inhibits oxidative stress-induced cell death of human Alzheimer's disease-derived and age-matched olfactory neuroepithelial cells via suppression of intracellular reactive oxygen species. J Alzheimers Dis. 2009;17(3):611-9.

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