Drug Information

Drug General Information
Drug ID
D0UO4B
Former ID
DNCL001590
Drug Name
RQ-00000005
Synonyms
Capromorelin
Drug Type
Small molecular drug
Indication Frailty [ICD10:R54] Phase 2 [522109]
Company
RaQualia Pharma
Structure
Download
2D MOL

3D MOL
Formula
C28H35N5O4
Canonical SMILES
CC(C)(C(=O)NC(COCC1=CC=CC=C1)C(=O)N2CCC3=NN(C(=O)C3(C2)<br />CC4=CC=CC=C4)C)N
InChI
1S/C28H35N5O4/c1-27(2,29)25(35)30-22(18-37-17-21-12-8-5-9-13-21)24(34)33-15-14-23-28(19-33,26(36)32(3)31-23)16-20-10-6-4-7-11-20/h4-13,22H,14-19,29H2,1-3H3,(H,30,35)/t22-,28-/m1/s1
InChIKey
KVLLHLWBPNCVNR-SKCUWOTOSA-N
CAS Number
CAS 193273-66-4
PubChem Compound ID
216208
PubChem Substance ID
9372788, 14762323, 14811141, 30419955, 57399743, 79335178, 103066835, 103080797, 103333741, 103983575, 113461113, 117570042, 128440393, 134341251, 135134762, 137116539, 142175296, 180371163, 198982121, 225105843, 227386111, 249583131
Target and Pathway
Target(s) Growth hormone secretagogue receptor type 1 Target Info Agonist [532719]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
NetPath Pathway Leptin Signaling Pathway
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 522109ClinicalTrials.gov (NCT00527046) Effects Of An Oral Growth Hormone Secretagogue In Older Functionally Limited Adults. U.S. National Institutes of Health.
Ref 532719Hypotensive effects of ghrelin receptor agonists mediated through a novel receptor. Br J Pharmacol. 2014 Mar;171(5):1275-86.

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