Drug Information

Drug General Information
Drug ID
D01HDP
Former ID
DCL000230
Drug Name
SLV 306
Drug Type
Small molecular drug
Indication Acute decompensated heart failure; Renal dysfunction [ICD9: 428, 428.0, 584, 585; ICD10:I50, N17-N19] Phase 2 [521684], [541643]
Company
Solvay Pharma
Structure
Download
2D MOL

3D MOL
Formula
C31H38N2O6
InChI
InChI=1S/C31H38N2O6/c1-2-39-29(37)24(15-14-22-10-4-3-5-11-22)20-31(18-8-9-19-31)30(38)32-25-17-16-23-12-6-7-13-26(23)33(28(25)36)21-27(34)35/h3-7,10-13,24-25H,2,8-9,14-21H2,1H3,(H,32,38)(H,34,35)/t24-,25+/m1/s1
InChIKey
XMQODGUTLZXUGZ-RPBOFIJWSA-N
PubChem Compound ID
3038505
PubChem Substance ID
10049041, 12015081, 14885552, 14934518, 36106218, 50066031, 51955015, 57353736, 111646238, 135141705, 175427034, 178103120, 180370621, 184528294, 198965767, 223703468, 226951262, 245868416, 252160569, 252669517
Target and Pathway
Target(s) Neutral endopeptidase Target Info Modulator [531869], [535988]
Endothelin converting enzyme Target Info Modulator [531869]
KEGG Pathway Renin-angiotensin system
Hematopoietic cell lineage
Protein digestion and absorption
Alzheimer's disease
NetPath Pathway EGFR1 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Reactome Metabolism of Angiotensinogen to Angiotensins
WikiPathways Metabolism of Angiotensinogen to Angiotensins
Primary Focal Segmental Glomerulosclerosis FSGS
Alzheimers Disease
References
Ref 521684ClinicalTrials.gov (NCT00160225) Study to Evaluate the Efficacy and Safety of Daglutril Compared to Placebo on Top of Losartan in Type 2 Diabetics With Overt Nephropathy and Well Controlled Hypertension. U.S. National Institutes of Health.
Ref 541643(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6506).
Ref 531869The dual endothelin converting enzyme/neutral endopeptidase inhibitor SLV-306 (daglutril), inhibits systemic conversion of big endothelin-1 in humans. Life Sci. 2012 Oct 15;91(13-14):743-8.
Ref 535988Effect of single doses of SLV306, an inhibitor of both neutral endopeptidase and endothelin-converting enzyme, on pulmonary pressures in congestive heart failure. Am J Cardiol. 2004 Jul 15;94(2):237-9.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.