Drug Information

Drug General Information
Drug ID
D0G7MV
Former ID
DCL000544
Drug Name
INCB24360
Drug Type
Small molecular drug
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Phase 2 [524471], [543000]
Company
Incyte
Structure
Download
2D MOL

3D MOL
Formula
C9H7ClFN5O2
InChI
InChI=1S/C9H7ClFN5O2/c10-5-3-4(1-2-6(5)11)13-9(14-17)7-8(12)16-18-15-7/h1-3,13,15H,(H2,12,16)/b9-7+
InChIKey
MUVQOOPKPBEAJZ-VQHVLOKHSA-N
PubChem Compound ID
11978742
PubChem Substance ID
17430900, 37428106, 75707816, 87329800, 103700349, 104154666, 131549341, 137155741, 138941762, 139430306, 186014879, 210275285, 210280934, 223218469, 226515204, 241179392, 249565901, 249714984, 251910824, 251970589, 252160827, 252215583, 252822165
Target and Pathway
Target(s) Indoleamine 2,3-dioxygenase Target Info Inhibitor [551022]
BioCyc Pathway Superpathway of tryptophan utilization
Tryptophan degradation
L-kynurenine degradation
Tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde
NAD de novo biosynthesis
KEGG Pathway Tryptophan metabolism
Metabolic pathways
African trypanosomiasis
NetPath Pathway TSLP Signaling Pathway
IL5 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
PathWhiz Pathway Tryptophan Metabolism
Reactome Tryptophan catabolism
WikiPathways Tryptophan metabolism
Metabolism of amino acids and derivatives
References
Ref 524471ClinicalTrials.gov (NCT01961115) INCB024360 and Vaccine Therapy in Treating Patients With Stage III-IV Melanoma. U.S. National Institutes of Health.
Ref 543000(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8221).
Ref 551022Incyte. Product Development Pipeline.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.