Drug General Information
Drug ID	D0Y5ZT
Former ID	DIB013290
Drug Name	KRP-203
Synonyms	KNF-299; KRP-203-P prodrug, Kyorin
Drug Type	Small molecular drug
Indication	Cutaneous lupus erythematosus [ICD9: 710; ICD10:M32]		Phase 2	[523356]
Company	Kyorin Pharmaceutical Co Ltd
Structure		Download 2D MOL 3D MOL
Formula	C24H26ClNO3S
Canonical SMILES	NC(CO)(CCc1ccc(Sc2cccc(OCc3ccccc3)c2)cc1Cl)CO.Cl
CAS Number	CAS 509088-69-1
PubChem Compound ID	11155874
Target and Pathway
Target(s)	Sphingosine 1-phosphate receptor 1	Target Info	Agonist	[532341], [532456]
KEGG Pathway	FoxO signaling pathway
	Sphingolipid signaling pathway
	Neuroactive ligand-receptor interaction
NetPath Pathway	IL4 Signaling Pathway
	TGF_beta_Receptor Signaling Pathway
	IL2 Signaling Pathway
Pathway Interaction Database	Fc-epsilon receptor I signaling in mast cells
	S1P3 pathway
	S1P1 pathway
	Sphingosine 1-phosphate (S1P) pathway
	PDGFR-beta signaling pathway
Reactome	G alpha (i) signalling events
	Lysosphingolipid and LPA receptors
WikiPathways	Signal Transduction of S1P Receptor
	Small Ligand GPCRs
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, Other
References
Ref 523356	ClinicalTrials.gov (NCT01294774) Safety and Efficacy of KRP203 in Subacute Cutaneous Lupus Erythematosus. U.S. National Institutes of Health.
Ref 532341	KRP-203, sphingosine 1-phosphate receptor type 1 agonist, ameliorates atherosclerosis in LDL-R-/- mice. Arterioscler Thromb Vasc Biol. 2013 Jul;33(7):1505-12.
Ref 532456	Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond. Nat Rev Drug Discov. 2013 Sep;12(9):688-702.

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