Drug General Information
Drug ID	D05GYL
Former ID	DIB012706
Drug Name	UR-63325
Synonyms	DP-1; Histamine H4 antagonist (allergic rhinitis, asthma), Palau
Indication	Allergic rhinitis [ICD9: 472.0, 477, 995.3; ICD10:J00, J30, J31.0, T78.4]		Phase 2	[523293]
Company	Palau Pharma SA
Structure		Download 2D MOL 3D MOL
Canonical SMILES	c1(nc2c(c(n1)N1CC(C1)NC)oc1c2CCC1)N
Target and Pathway
Target(s)	Histamine H4 receptor	Target Info	Antagonist	[531749]
KEGG Pathway	Neuroactive ligand-receptor interaction
Reactome	Histamine receptors
	G alpha (i) signalling events
WikiPathways	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, Other
References
Ref 523293	ClinicalTrials.gov (NCT01260753) Proof of Activity Study of UR-63325 in Allergic Rhinitis Induced by Nasal Challenge. U.S. National Institutes of Health.
Ref 531749	Azines as histamine H4 receptor antagonists. Front Biosci (Schol Ed). 2012 Jan 1;4:967-87.

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