Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D04QWQ
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| Former ID |
DNCL001683
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| Drug Name |
VX-509
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| Drug Type |
Small molecular drug
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| Company |
Vertex Pharmaceuticals
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| Structure |
|
Download2D MOL |
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| Formula |
C18H19F3N6O
|
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| InChI |
InChI=1S/C18H19F3N6O/c1-3-17(2,16(28)25-10-18(19,20)21)27-13-6-8-23-15(26-13)12-9-24-14-11(12)5-4-7-22-14/h4-9H,3,10H2,1-2H3,(H,22,24)(H,25,28)(H,23,26,27)/t17-/m1/s1
|
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| InChIKey |
ASUGUQWIHMTFJL-QGZVFWFLSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Tyrosine-protein kinase JAK3 | Target Info | Inhibitor | [532777], [533175] | |
| References | |||||
| Ref 524261 | ClinicalTrials.gov (NCT01830985) A Phase 2/3 Open-label Extension Study to Evaluate Long-Term Safety and Efficacy With VX-509 in Subjects With Rheumatoid Arthritis. U.S. National Institutes of Health. | ||||
| Ref 543061 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8309). | ||||
| Ref 532777 | Selective JAK inhibitors in development for rheumatoid arthritis. Expert Opin Investig Drugs. 2014 Aug;23(8):1067-77. | ||||
| Ref 533175 | VX-509 (decernotinib) is a potent and selective janus kinase 3 inhibitor that attenuates inflammation in animal models of autoimmune disease. J Pharmacol Exp Ther. 2015 May;353(2):405-14. | ||||
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