Drug Information

Drug General Information
Drug ID
D0F4ZY
Former ID
DCL000312
Drug Name
KW-6002
Synonyms
Istradefylline; KW 6002; Istradefylline [USAN:INN]; Istradefylline (JAN/USAN/INN); (E)-8-(3,4-Dimethoxystyryl)-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione; (E)-8-(3,4-Dimethoxystyryl)-1,3-diethyl-7-methylxanthine; 8-((1E)-2-(3,4-Dimethoxyphenyl)ethenyl)-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione; 8-(2-(3,4-dimethoxyphenyl)ethenyl)-1,3-diethyl-3,7-dihydro-7-methyl-1H-purine-2,6-dione; 8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methylpurine-2,6-dione
Drug Type
Small molecular drug
Indication Parkinson's disease [ICD9: 332; ICD10:G20] Phase 3 [551079]
Company
Kyowa Hakko Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C20H24N4O4
Canonical SMILES
CCN1C2=C(C(=O)N(C1=O)CC)N(C(=N2)C=CC3=CC(=C(C=C3)OC)OC)<br />C
InChI
1S/C20H24N4O4/c1-6-23-18-17(19(25)24(7-2)20(23)26)22(3)16(21-18)11-9-13-8-10-14(27-4)15(12-13)28-5/h8-12H,6-7H2,1-5H3/b11-9+
InChIKey
IQVRBWUUXZMOPW-PKNBQFBNSA-N
CAS Number
CAS 155270-99-8
PubChem Compound ID
5311037
PubChem Substance ID
7978842, 11056223, 12014869, 14878146, 39340766, 47206484, 50027674, 50629398, 57359333, 85210094, 92729739, 103276933, 104061724, 114155109, 126671671, 134338968, 134339069, 134343014, 135175557, 135697573, 137005694, 140175846, 144116113, 152105687, 152159601, 152258274, 152343827, 160647112, 162011669, 162222240, 163408039, 163914047, 164777218, 170466116, 172093763, 172912718, 174527720, 175437836, 178102242, 179150002, 185975314, 198959942, 206245955, 208265417, 223378751, 223435458, 223496120, 223554827, 223660299, 223704923
Target and Pathway
Target(s) Adenosine A2a receptor Target Info Modulator
KEGG Pathway Rap1 signaling pathway
Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Parkinson's disease
Alcoholism
Pathway Interaction Database HIF-2-alpha transcription factor network
PathWhiz Pathway Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Reactome NGF-independant TRKA activation
Adenosine P1 receptors
G alpha (s) signalling events
Surfactant metabolism
WikiPathways Nucleotide GPCRs
Monoamine Transport
GPCRs, Class A Rhodopsin-like
NGF signalling via TRKA from the plasma membrane
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 551079Clinical pipeline report, company report or official report of Kyowa Hakko Pharmaceuticals.

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