Drug Information

Drug General Information
Drug ID
D0W9VW
Former ID
DCL000255
Drug Name
TZP-101
Drug Type
Small molecular drug
Indication Ileus; Gastroparesis; Miscellaneous gastrointestinal disorders [ICD9: 530-558, 536.3, 537.2, 560.1, 560.31, 777.1, 777.4; ICD10:K20-K64, K31.5, K31.8, K56.0, K56.3, K56.7, P76.1] Phase 2b [536527], [540467]
Company
Tranzyme
Structure
Download
2D MOL

3D MOL
Formula
C30H39FN4O4
InChI
InChI=1S/C30H39FN4O4/c1-19-18-33-27(23-12-13-23)30(38)35(3)20(2)28(36)34-25(17-21-10-14-24(31)15-11-21)29(37)32-16-6-8-22-7-4-5-9-26(22)39-19/h4-5,7,9-11,14-15,19-20,23,25,27,33H,6,8,12-13,16-18H2,1-3H3,(H,32,37)(H,34,36)/t19-,20-,25-,27+/m1/s1
InChIKey
WGYPAJVJMXQXTR-ABNZCKJZSA-N
PubChem Compound ID
11526696
PubChem Substance ID
16628629, 23653158, 42644730, 80359330, 134338913, 135263009, 135626702, 136349987, 136963280, 141855184, 160682643, 163349824, 178100514, 196409672, 198971919, 227082748, 248554928
Target and Pathway
Target(s) Growth hormone secretagogue receptor type 1 Target Info Agonist [537004], [537157], [537305]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
NetPath Pathway Leptin Signaling Pathway
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 536527Emerging drugs for postoperative ileus. Expert Opin Emerg Drugs. 2007 Nov;12(4):619-26.
Ref 540467(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3535).
Ref 537004Effect of the ghrelin receptor agonist TZP-101 on colonic transit in a rat model of postoperative ileus. Eur J Pharmacol. 2009 Feb 14;604(1-3):132-7. Epub 2008 Dec 14.
Ref 537157Ghrelin receptor agonist (TZP-101) accelerates gastric emptying in adults with diabetes and symptomatic gastroparesis. Aliment Pharmacol Ther. 2009 Jun 1;29(11):1179-87. Epub 2009 Feb 27.
Ref 537305Contribution of protein binding to the pharmacokinetics of the ghrelin receptor agonist TZP-101 in healthy volunteers and adults with symptomatic gastroparesis: two randomized, double-blind studies and a binding profile study. Clin Drug Investig. 2009;29(6):409-18. doi: 10.2165/00044011-200929060-00004.

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