Drug Information

Drug General Information
Drug ID
D00NVM
Former ID
DCL000995
Drug Name
SNS-595
Synonyms
Voreloxin; Vosaroxin; AG 7352; SNS 595; SPC 595; AG 7352 (TN); AG-7352; SNS 595 (TN); SPC 595 (TN); SPC-595; Voreloxin (TN); Voreloxin (USAN); SNS-595 (TN); 1,4-Dihydro-7-(3-methoxy-4-methylamino-1-pyrrolidinyl)-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid
Drug Type
Small molecular drug
Indication Ovarian cancer [ICD9: 183; ICD10:C56] Phase 2 [536839]
Company
Sunesis Pharmaceuticals Inc
Structure
Download
2D MOL

3D MOL
Formula
C18H19N5O4S
Canonical SMILES
CNC1CN(CC1OC)C2=NC3=C(C=C2)C(=O)C(=CN3C4=NC=CS4)C(=O)O
InChI
1S/C18H19N5O4S/c1-19-12-8-22(9-13(12)27-2)14-4-3-10-15(24)11(17(25)26)7-23(16(10)21-14)18-20-5-6-28-18/h3-7,12-13,19H,8-9H2,1-2H3,(H,25,26)/t12-,13-/m0/s1
InChIKey
XZAFZXJXZHRNAQ-STQMWFEESA-N
CAS Number
CAS 175414-77-4
PubChem Compound ID
9952884
PubChem Substance ID
14928277, 24222816, 46049494, 78436178, 87550951, 96024717, 103259337, 126671549, 129761433, 135262318, 137156821, 141015493, 152258248, 160647084, 172919846, 184696702, 185990440, 198984748, 223404382, 223661862, 224490564, 226088111, 226970157, 252216591, 252473841
Target and Pathway
Target(s) DNA topoisomerase II Target Info Modulator
References
Ref 536839Emerging drugs for ovarian cancer. Expert Opin Emerg Drugs. 2008 Sep;13(3):523-36.

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