Drug Information

Drug General Information
Drug ID
D0Z5VQ
Former ID
DNCL001899
Drug Name
Terutroban sodium
Drug Type
Small molecular drug
Indication Thromboembolism [ICD9: 437.6, 453, 671.5, 671.9; ICD10:I80-I82] Discontinued in Phase 3 [546968]
Company
Servier
Structure
Download
2D MOL

3D MOL
Formula
C20H21ClNNaO4S
Canonical SMILES
CC1=C(C2=C(CC(CC2)NS(=O)(=O)C3=CC=C(C=C3)Cl)C=C1)CCC(=O<br />)[O-].[Na+]
InChI
1S/C20H22ClNO4S.Na/c1-13-2-3-14-12-16(6-9-19(14)18(13)10-11-20(23)24)22-27(25,26)17-7-4-15(21)5-8-17;/h2-5,7-8,16,22H,6,9-12H2,1H3,(H,23,24);/q;+1/p-1/t16-;/m1./s1
InChIKey
BQMSKINGUUUIHE-PKLMIRHRSA-M
PubChem Compound ID
23674098
PubChem Substance ID
16258174, 22395191, 42257603, 56042790, 57387285, 80857112, 135267372
Target and Pathway
Target(s) Thromboxane A2 receptor Target Info Antagonist [528120]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Platelet activation
Reactome Prostanoid ligand receptors
G alpha (q) signalling events
G alpha (12/13) signalling events
Thromboxane signalling through TP receptor
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
Signal amplification
GPCR ligand binding
GPCR downstream signaling
References
Ref 546968Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800011626)
Ref 528120Terutroban and endothelial TP receptors in atherogenesis. Med Sci (Paris). 2006 Apr;22(4):437-43.

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