Drug General Information
Drug ID
D0CG0G
Former ID
DIB008924
Drug Name
11beta-hydroxysteroid dehydrogenase-1 (HSD1) inhibitors
Synonyms
11beta-HSD1 inhibitors (metabolic disorders), Merck
Indication Atherosclerosis [ICD9: 414.0, 440; ICD10:I70] Investigative [552025]
Company
Merck & Co Inc
Structure
Download
2D MOL

3D MOL

Canonical SMILES
O=S(=O)(CC[C@]12CC[C@](c3n(c(nn3)c3ccccc3C(F)(F)F)C)(CC<br />1)CC2)CC
Target and Pathway
Target(s) Corticosteroid 11-beta-dehydrogenase, isozyme 1 Target Info Inhibitor [543704]
KEGG Pathway Steroid hormone biosynthesis
Metabolism of xenobiotics by cytochrome P450
Metabolic pathways
Chemical carcinogenesis
NetPath Pathway IL1 Signaling Pathway
FSH Signaling Pathway
PathWhiz Pathway Steroidogenesis
Reactome Glucocorticoid biosynthesis
WikiPathways Prostaglandin Synthesis and Regulation
Metabolism of steroid hormones and vitamin D
Glucocorticoid & Mineralcorticoid Metabolism
References
Ref 552025High-throughput screening of 11beta-hydroxysteroid dehydrogenase type 1 in scintillation proximity assay format. Assay Drug Dev Technol. 2005 Aug;3(4):377-84.
Ref 543704(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2763).

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.