Drug Information

Drug General Information
Drug ID
D01QYQ
Former ID
DIB013446
Drug Name
ATL-844
Synonyms
ATL-618; MRS-1754; ATL-GW-22; ATL-GW-8; A2B adenosine receptor antagonists, Adenosine/Ortho-McNeil; A2B adenosine receptor antagonists (oral, asthma/diabetes), Adenosine Therapeutics; A2B adenosine receptor antagonists (oral, asthma/diabetes), Clinical Data
Drug Type
Small molecular drug
Indication Asthma [ICD10:J45] Investigative [467730]
Company
University of Virginia
Structure
Download
2D MOL

3D MOL
Formula
C26H26N6O4
InChI
InChI=1S/C26H26N6O4/c1-3-13-31-24-22(25(34)32(14-4-2)26(31)35)29-23(30-24)18-7-11-20(12-8-18)36-16-21(33)28-19-9-5-17(15-27)6-10-19/h5-12H,3-4,13-14,16H2,1-2H3,(H,28,33)(H,29,30)
InChIKey
AJBBEYXFRYFVNM-UHFFFAOYSA-N
CAS Number
CAS 264622-58-4
PubChem Compound ID
6603931
PubChem Substance ID
11111478, 11646411, 14883713, 17405290, 24278793, 43223723, 48395000, 50106547, 50106548, 50106549, 52226893, 53777835, 56463251, 57370997, 85209186, 85231139, 85789113, 92304376, 103180854, 103985562, 114637051, 123051060, 124749949, 124799288, 124880758, 124880759, 127413921, 135650653, 135651182, 135698696, 162023183, 163122828, 170474554, 178127135, 181285846, 227454973, 241055655, 241376109, 249617683, 252156760, 252435845, 252451063
Target and Pathway
Target(s) Adenosine A2b receptor Target Info Antagonist [543534]
KEGG Pathway Rap1 signaling pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Alcoholism
NetPath Pathway TGF_beta_Receptor Signaling Pathway
TCR Signaling Pathway
Pathway Interaction Database C-MYB transcription factor network
PathWhiz Pathway Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
Reactome Adenosine P1 receptors
G alpha (s) signalling events
Surfactant metabolism
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 467730(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 449).
Ref 543534(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 20).

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