Drug Information

Drug General Information
Drug ID
D0NN5F
Former ID
DIB009360
Drug Name
BChE inhibitors
Synonyms
BChE inhibitors (imaging, Alzheimers disease); BChE inhibitors (imaging, Alzheimers disease), University ofNebraska Medical Center; Imaging/therapeutic butyrylcholinesterase inhibitors (Alzheimers disease), UNMC
Indication Alzheimer disease [ICD9: 331; ICD10:G30] Investigative [552019]
Company
University of Nebraska Medical Center
Structure
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2D MOL

3D MOL
Canonical SMILES
[nH]1c(=O)n(cc(c1=O)C)[C@H]1C[C@@H]([C@H](O1)COP1(=O)Oc<br />2c(cc(c(c2CO1)F)C(C)(C)C)C(C)(C)C)[18F]
Target and Pathway
Target(s) Cholinesterase Target Info Inhibitor [543635]
PANTHER Pathway Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
Nicotinic acetylcholine receptor signaling pathway
WikiPathways Irinotecan Pathway
References
Ref 552019Screening assays for cholinesterases resistant to inhibition by organophosphorus toxicants. Anal Biochem. 2004 Jun 1;329(1):131-8.
Ref 543635(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2471).

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