Drug General Information
Drug ID	D0TA3V
Former ID	DIB004172
Drug Name	ADC-5510
Synonyms	ADC-02265510; ADC-5510; ADL-5510; Centrally acting mu opoid receptor antagonists, Adolor
Indication	Movement disorder [ICD10:R25]		Investigative	[543764]
Company	Adolor Corp
Structure		Download 2D MOL 3D MOL
Canonical SMILES	C[C@]1(c2cc(ccc2)O)[C@H](CN2C[C@@H](N(C[C@H]2C1)C(=O)c1<br />ccccc1)c1ccccc1)C
Target and Pathway
Target(s)	Mu-type opioid receptor	Target Info	Antagonist	[543764]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Estrogen signaling pathway
	Morphine addiction
NetPath Pathway	TCR Signaling Pathway
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Enkephalin release
Pathway Interaction Database	IL4-mediated signaling events
Reactome	Peptide ligand-binding receptors
	G alpha (i) signalling events
WikiPathways	TCR Signaling Pathway
	GPCRs, Class A Rhodopsin-like
	Peptide GPCRs
	Opioid Signalling
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 543764	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 319).
Ref 543764	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 319).

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