Drug Information

Drug General Information
Drug ID
D0C4BI
Former ID
DIB001462
Drug Name
EX-1314
Synonyms
BMS-317180; BMS-604992; BMS-606056; Ghrelin agonists, BMS; Ghrelin agonists, Elixir; Growth hormone secretagogues, BMS; Growthhormone secretagogues, Elixir
Drug Type
Small molecular drug
Indication Cachexia [ICD9: 799.4; ICD10:R64] Investigative [543633]
Company
Bristol-Myers Squibb Co
Structure
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2D MOL

3D MOL
Formula
C24H32ClN7O5
Canonical SMILES
N(CC(=O)N)(C)C(=O)OCc1cccc2nnc([C@@H](COCc3ccccc3)NC(=O<br />)C(C)(C)N)n12.Cl.Cl
PubChem Compound ID
72941845
Target and Pathway
Target(s) Growth hormone secretagogue receptor type 1 Target Info Agonist [543633]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
NetPath Pathway Leptin Signaling Pathway
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 543633(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 246).
Ref 543633(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 246).

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