Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D01YGY
|
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| Former ID |
DIB012081
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| Drug Name |
UC-1011
|
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| Synonyms |
UC-1011; UC-2021; UC-2025; GABA A receptor antagonists (Alzheimer's disease); GABA A receptor antagonists (Alzheimer's disease), Umecrine; 3beta-20beta-dihydroxy-5alpha-pregnane; 3beta-20beta-dihydroxy-5alpha-pregnane (Alzheimer's disease), Umecrine
|
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| Indication | Alzheimer disease [ICD9: 331; ICD10:G30] | Investigative | [1] | ||
| Company |
Umecrine AB
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| Structure |
|
Download2D MOL |
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| Canonical SMILES |
[C@@]12([C@H]([C@H]3[C@@H]([C@@]4([C@@H](CC3)C[C@H](CC4<br />)O)C)CC2)CC[C@@H]1[C@@H](O)C)C
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| Target and Pathway | |||||
| Target(s) | GABA A receptor | Target Info | Antagonist | [1] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
| Retrograde endocannabinoid signaling | |||||
| GABAergic synapse | |||||
| Morphine addiction | |||||
| Nicotine addiction | |||||
| Reactome | Ligand-gated ion channel transport | ||||
| GABA A receptor activation | |||||
| WikiPathways | SIDS Susceptibility Pathways | ||||
| Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | |||||
| Iron uptake and transport | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 415). | ||||
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