Drug Information
Drug General Information | |||||
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Drug ID |
D07IEM
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Former ID |
DCL000045
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Drug Name |
AMG-8562
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Drug Type |
Small molecular drug
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Indication | Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] | Terminated | [547931] | ||
Therapeutic Class |
Analgesics
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Company |
Amgen
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Structure |
Download2D MOL |
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Formula |
C24H25F3N2O2
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Canonical SMILES |
C1CCN(CC1)C2=C(C=CC(=C2)C(F)(F)F)C=CC(=O)NC3=CC=CC4=C3C<br />C(C4)O
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InChI |
1S/C24H25F3N2O2/c25-24(26,27)18-9-7-16(22(14-18)29-11-2-1-3-12-29)8-10-23(31)28-21-6-4-5-17-13-19(30)15-20(17)21/h4-10,14,19,30H,1-3,11-13,15H2,(H,28,31)/b10-8+/t19-/m1/s1
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InChIKey |
HAZYXDWNLMGLIS-LHUXKHBRSA-N
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | Vanilloid receptor 1 | Target Info | Blocker | [537396] | |
NetPath Pathway | IL2 Signaling Pathway | ||||
Pathway Interaction Database | Trk receptor signaling mediated by the MAPK pathway | ||||
Trk receptor signaling mediated by PI3K and PLC-gamma | |||||
Reactome | TRP channels | ||||
References |
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