Drug Information
Drug General Information | |||||
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Drug ID |
D0AK4H
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Former ID |
DIB015210
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Drug Name |
AMG-429
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Synonyms |
AMG-429; KDR inhibitors (anticancer), Amgen; VEGFR-2 inhibitors (anticancer); VEGFR-2 inhibitors (anticancer), Amgen
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Indication | Cancer [ICD9: 140-229; ICD10:C00-C96] | Investigative | [1] | ||
Company |
Amgen Inc
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Structure |
Download2D MOL |
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Canonical SMILES |
c1(c(cc2c(c1)c(ccn2)Oc1cc2c(cc1)c(nn2C)NC(=O)c1cc(ccc1)<br />C(F)(F)F)OC)OC
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Target and Pathway | |||||
Target(s) | Vascular endothelial growth factor receptor 2 | Target Info | Inhibitor | [1] | |
KEGG Pathway | Ras signaling pathway | ||||
Rap1 signaling pathway | |||||
Cytokine-cytokine receptor interaction | |||||
Endocytosis | |||||
PI3K-Akt signaling pathway | |||||
VEGF signaling pathway | |||||
Focal adhesion | |||||
Proteoglycans in cancer | |||||
NetPath Pathway | IL2 Signaling Pathway | ||||
PANTHER Pathway | Angiogenesis | ||||
VEGF signaling pathway | |||||
Pathway Interaction Database | HIF-2-alpha transcription factor network | ||||
Beta3 integrin cell surface interactions | |||||
Signaling events mediated by TCPTP | |||||
SHP2 signaling | |||||
S1P1 pathway | |||||
VEGF and VEGFR signaling network | |||||
Integrins in angiogenesis | |||||
Signaling events mediated by VEGFR1 and VEGFR2 | |||||
Notch-mediated HES/HEY network | |||||
Reactome | Neurophilin interactions with VEGF and VEGFR | ||||
VEGF binds to VEGFR leading to receptor dimerization | |||||
Integrin cell surface interactions | |||||
EPHA-mediated growth cone collapse | |||||
VEGFA-VEGFR2 Pathway | |||||
VEGFR2 mediated cell proliferation | |||||
WikiPathways | Focal Adhesion | ||||
Nifedipine Activity | |||||
Cardiac Progenitor Differentiation | |||||
Signaling by VEGF | |||||
Angiogenesis | |||||
References | |||||
REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1813). | ||||
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