TTD | Drug: D00AJI

Drug General Information
Drug ID	D00AJI
Former ID	DIB000249
Drug Name	PF-4480682
Indication	Neuropathic pain [ICD9: 356.0, 356.8; ICD10:G64, G90.0]		Discontinued in Phase 2	[548430]
Company	Pfizer Inc
Target and Pathway
Target(s)	GABA A receptor delta subunit	Target Info	Modulator	[550179]
Target(s)	Gamma-aminobutyric-acid receptor alpha-2 subunit	Target Info	Modulator	[550179]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Retrograde endocannabinoid signaling
	GABAergic synapse
	Morphine addiction
	Nicotine addictionhsa04080:Neuroactive ligand-receptor interaction
	Nicotine addiction
Reactome	Ligand-gated ion channel transport
Reactome	GABA A receptor activation
WikiPathways	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
WikiPathways	Iron uptake and transport
References
Ref 548430	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025530)
Ref 550179	WO patent application no. 2014,1515,17, Methods of improving microvascular integrity.

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Drug Information