Drug Information

Drug General Information
Drug ID
D0P2KG
Former ID
DCL000404
Drug Name
GSK1144814
Indication Schizophrenia [ICD9: 295; ICD10:F20] Discontinued in Phase 1 [522978]
Company
GSK
Target and Pathway
Target(s) Nigral tachykinin NK(3) receptor Target Info Modulator
Substance-P receptor Target Info Modulator
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interactionhsa04020:Calcium signaling pathway
Neuroactive ligand-receptor interaction
Measles
PANTHER Pathway CCKR signaling map ST
Reactome G alpha (q) signalling eventsR-HSA-416476:G alpha (q) signalling events
WikiPathways Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signalingWP706:SIDS Susceptibility Pathways
Spinal Cord Injury
GPCR downstream signaling
References
Ref 522978ClinicalTrials.gov (NCT01090440) Pharmacokinetics, Effect of Food, Safety and Tolerability of a New Tablet Formulation of GSK1144814 in Healthy Subjects. U.S. National Institutes of Health.

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