Drug General Information
Drug ID	D0LW1Y
Former ID	DIB001204
Drug Name	GFT-505
Synonyms	GFT-1007; PPAR activator (dyslipidemia/type 2 diabetes), Genfit
Indication	Type 2 diabetes [ICD9: 250; ICD10:E11]		Phase 2	[548380]
Company	Genfit SA
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	Peroxisomeproliferator activated receptor delta	Target Info	Modulator
	Peroxisome proliferator activated receptor alpha	Target Info	Modulator
KEGG Pathway	PPAR signaling pathway
	Wnt signaling pathway
	Pathways in cancer
	Acute myeloid leukemiahsa03320:PPAR signaling pathway
	cAMP signaling pathway
	Adipocytokine signaling pathway
	Glucagon signaling pathway
	Non-alcoholic fatty liver disease (NAFLD)
	Hepatitis C
NetPath Pathway	IL2 Signaling Pathway
PANTHER Pathway	Wnt signaling pathway
Pathway Interaction Database	Presenilin action in Notch and Wnt signaling
	RXR and RAR heterodimerization with other nuclear receptorrxr_vdr_pathway:RXR and RAR heterodimerization with other nuclear receptor
Reactome	Import of palmitoyl-CoA into the mitochondrial matrix
	Regulation of pyruvate dehydrogenase (PDH) complex
	Nuclear Receptor transcription pathwayR-HSA-1368082:RORA activates gene expression
	BMAL1:CLOCK,NPAS2 activates circadian gene expression
	PPARA activates gene expression
	YAP1- and WWTR1 (TAZ)-stimulated gene expression
	Transcriptional activation of mitochondrial biogenesis
	Activation of gene expression by SREBF (SREBP)
	Transcriptional regulation of white adipocyte differentiation
	Nuclear Receptor transcription pathway
	Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
	Circadian Clock
WikiPathways	Wnt Signaling Pathway and Pluripotency
	Nuclear Receptors in Lipid Metabolism and Toxicity
	NRF2 pathway
	Nuclear Receptors Meta-Pathway
	Vitamin D Receptor Pathway
	Ectoderm Differentiation
	Adipogenesis
	Nuclear ReceptorsWP299:Nuclear Receptors in Lipid Metabolism and Toxicity
	Estrogen Receptor Pathway
	PPAR Alpha Pathway
	Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
	Transcriptional Regulation of White Adipocyte Differentiation
	YAP1- and WWTR1 (TAZ)-stimulated gene expression
	Activation of Gene Expression by SREBP (SREBF)
	SREBF and miR33 in cholesterol and lipid homeostasis
	Circadian Clock
	Nuclear Receptors
References
Ref 548380	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025107)

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