Drug Information

Drug General Information
Drug ID
D0Z6DE
Former ID
DCL000967
Drug Name
RPSGL-Ig
Indication Delayed graft function; Heart transplantation [ICD9: 996; ICD10:T86] Phase 2 [537129]
Company
Thios Pharmaceuticals
Target and Pathway
Target(s) P-selectin Target Info Inhibitor [533194], [537129]
KEGG Pathway Cell adhesion molecules (CAMs)
Malaria
Staphylococcus aureus infection
Pathway Interaction Database IL4-mediated signaling events
amb2 Integrin signaling
Reactome Platelet degranulation
Cell surface interactions at the vascular wall
WikiPathways Human Complement System
Spinal Cord Injury
Cell surface interactions at the vascular wall
References
Ref 537129New developments in immunosuppressive therapy for heart transplantation. Expert Opin Emerg Drugs. 2009 Mar;14(1):1-21.
Ref 533194rPSGL-1-Ig, a recombinant PSGL-1-Ig fusion protein, ameliorates LPS-induced acute lung injury in mice by inhibiting neutrophil migration. Cell Mol Biol (Noisy-le-grand). 2015 Feb 28;61(1):1-6.
Ref 537129New developments in immunosuppressive therapy for heart transplantation. Expert Opin Emerg Drugs. 2009 Mar;14(1):1-21.

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