Drug Information

Drug General Information
Drug ID
D0G7YF
Former ID
DIB009628
Drug Name
VX-467
Synonyms
JAK 3 inhibitor (inflammation), Vertex
Indication Inflammatory disease [ICD9: 140-229, 147, 173, 573.3, 710-719; ICD10:C11, C44, K75.9, M00-M25] Investigative [543546]
Company
Vertex Pharmaceuticals Inc
Target and Pathway
Target(s) Tyrosine-protein kinase JAK3 Target Info Inhibitor [543546]
KEGG Pathway Chemokine signaling pathway
PI3K-Akt signaling pathway
Signaling pathways regulating pluripotency of stem cells
Jak-STAT signaling pathway
Measles
HTLV-I infection
Epstein-Barr virus infection
Viral carcinogenesis
Primary immunodeficiency
PANTHER Pathway Interleukin signaling pathway
JAK/STAT signaling pathway
PDGF signaling pathway
Pathway Interaction Database IL4-mediated signaling events
CD40/CD40L signaling
Signaling events mediated by TCPTP
SHP2 signaling
IL2-mediated signaling events
IL2 signaling events mediated by PI3K
IL2 signaling events mediated by STAT5
Reactome GPVI-mediated activation cascade
Interleukin-7 signaling
G beta:gamma signalling through PI3Kgamma
Interleukin-2 signaling
RAF/MAP kinase cascade
Interleukin receptor SHC signaling
WikiPathways IL-2 Signaling Pathway
IL-4 Signaling Pathway
Interleukin-2 signaling
Interleukin-7 signaling
Oncostatin M Signaling Pathway
IL-9 Signaling Pathway
IL-7 Signaling Pathway
Interleukin-3, 5 and GM-CSF signaling
References
Ref 543546(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2049).
Ref 543546(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2049).

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