Drug Information

Drug General Information
Drug ID
D06KXS
Former ID
DNC012529
Drug Name
PT-112
Drug Type
Small molecular drug
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Phase 1 [524955]
Structure
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2D MOL

3D MOL
Formula
C16H16BrClFN3OS
Canonical SMILES
CCOC1=C(C(=C(C=C1)F)CCNC(=S)NC2=NC=C(C=C2)Br)Cl
InChI
1S/C16H16BrClFN3OS/c1-2-23-13-5-4-12(19)11(15(13)18)7-8-20-16(24)22-14-6-3-10(17)9-21-14/h3-6,9H,2,7-8H2,1H3,(H2,20,21,22,24)
InChIKey
DTHZUSMREBJMBT-UHFFFAOYSA-N
PubChem Compound ID
3001152
Target and Pathway
Target(s) HIV-1 reverse transcriptase Target Info Inhibitor [534243]
References
Ref 524955ClinicalTrials.gov (NCT02266745) A Phase 1 Study of PT-112 Injection in Subjects With Advanced Solid Tumors. U.S. National Institutes of Health.
Ref 534243J Med Chem. 1996 Oct 11;39(21):4261-74.Phenethylthiazolylthiourea (PETT) compounds as a new class of HIV-1 reverse transcriptase inhibitors. 2. Synthesis and further structure-activity relationship studies of PETT analogs.

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