Drug Information
Drug General Information | |||||
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Drug ID |
D0X0CB
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Former ID |
DIB010726
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Drug Name |
Lumacaftor
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Synonyms |
VRT-325; VRT-422; VRT-532; VX-809; CFTR correctors (cystic fibrosis), Vertex; Cystic fibrosis transmembrane regulator corrector (cystic fibrosis), Vertex
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Drug Type |
Small molecular drug
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Company |
Vertex Pharmaceuticals Inc
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Structure |
Download2D MOL |
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Formula |
C24H18F2N2O5
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InChI |
InChI=1S/C16H14N2O/c1-11-7-8-16(19)13(9-11)15-10-14(17-18-15)12-5-3-2-4-6-12/h2-10,19H,1H3,(H,17,18)
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InChIKey |
AQWKVJFRGORALM-UHFFFAOYSA-N
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | cystic fibrosis transmembrane conductance regulator | Target Info | Regulator | [532863] | |
WikiPathways | ABC-family proteins mediated transport | ||||
References | |||||
Ref 522612 | ClinicalTrials.gov (NCT00865904) Study of VX-809 in Cystic Fibrosis Subjects With the ???508-CFTR Gene Mutation. U.S. National Institutes of Health. | ||||
Ref 542504 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7481). |
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