Drug Information

Drug General Information
Drug ID
D0J7DI
Former ID
DIB009319
Drug Name
KAI-1455
Drug Type
Small molecular drug
Indication Ischemic reperfusion injury [ICD10:I00-I99] Discontinued in Phase 1 [548522]
Company
KAI Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C9H18N2O4
Canonical SMILES
CCCC(C)(COC(=O)N)COC(=O)N
InChI
1S/C9H18N2O4/c1-3-4-9(2,5-14-7(10)12)6-15-8(11)13/h3-6H2,1-2H3,(H2,10,12)(H2,11,13)
InChIKey
NPPQSCRMBWNHMW-UHFFFAOYSA-N
PubChem Compound ID
4064
PubChem Substance ID
89640, 7366092, 7847442, 7979904, 8152550, 10527934, 14822610, 17389535, 24896728, 29223175, 46508142, 48416220, 48425274, 50021624, 50893943, 57654362, 68530538, 87245066, 103255535, 104305326, 108165187, 117425357, 124890349, 125353471, 126677741, 128736426, 134222669, 134337962, 134338694, 134338822, 134971019, 136949641, 137001618, 142043533, 144204614, 144207530, 144238911, 160963718, 164827462, 175268791, 176254515, 177513105, 178103799, 179225303, 184532185, 198991699, 223674399, 226405717, 249946527, 252403288
Target and Pathway
Target(s) Protein kinase C, epsilon type Target Info Stimulator [544337]
KEGG Pathway cGMP-PKG signaling pathway
Sphingolipid signaling pathway
Vascular smooth muscle contraction
Tight junction
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
Inflammatory mediator regulation of TRP channels
Type II diabetes mellitus
MicroRNAs in cancer
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway Alpha adrenergic receptor signaling pathway
Alzheimer disease-amyloid secretase pathway
Angiogenesis
Apoptosis signaling pathway
EGF receptor signaling pathway
Endothelin signaling pathway
FGF signaling pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Inflammation mediated by chemokine and cytokine signaling pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
VEGF signaling pathway
Wnt signaling pathway
5HT2 type receptor mediated signaling pathway
Histamine H1 receptor mediated signaling pathway
Oxytocin receptor mediated signaling pathway
Thyrotropin-releasing hormone receptor signaling pathway
CCKR signaling map ST
Pathway Interaction Database Endothelins
LPA receptor mediated events
TCR signaling in na&#xef
LPA4-mediated signaling events
CDC42 signaling events
TCR signaling in na&#xef
Thromboxane A2 receptor signaling
Role of Calcineurin-dependent NFAT signaling in lymphocytes
IL2-mediated signaling events
PDGFR-beta signaling pathway
IL8- and CXCR1-mediated signaling events
Regulation of Ras family activation
Downstream signaling in na&#xef
Reactome Effects of PIP2 hydrolysis
DAG and IP3 signaling
Role of phospholipids in phagocytosis
G alpha (z) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Calcium Regulation in the Cardiac Cell
Wnt Signaling Pathway
Wnt Signaling Pathway and Pluripotency
G Protein Signaling Pathways
Myometrial Relaxation and Contraction Pathways
Oncostatin M Signaling Pathway
miRs in Muscle Cell Differentiation
GPCR downstream signaling
Effects of PIP2 hydrolysis
Physiological and Pathological Hypertrophy of the Heart
References
Ref 548522Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026294)
Ref 544337Protein kinase C, an elusive therapeutic target?. Nat Rev Drug Discov. 2012 December; 11(12): 937-957.

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