Drug Information

Drug General Information
Drug ID
D00MAN
Former ID
DIB009942
Drug Name
GRC-6211
Synonyms
GRC-6127; TRPV1 antagonists (asthma), Glenmark/Lilly; TRPV1 antagonists (incontinence), Glenmark/Lilly; TRPV1 antagonists (pain), Glenmark/Lilly; Transient receptor potential vanilloid sub-family 1 (pain), Glenmark/ Lilly; Vanilloid receptor VR1 antagonists (incontinence/pain/asthma), Glenmark/Lilly
Drug Type
Small molecular drug
Indication Asthma [ICD10:J45] Phase 1 [548350]
Company
Glenmark Pharmaceuticals Ltd
Structure
Download
2D MOL

3D MOL
Formula
C13H11NO5
Canonical SMILES
CCN1C=C(C(=O)C2=CC3=C(C=C21)OCO3)C(=O)O
InChI
1S/C13H11NO5/c1-2-14-5-8(13(16)17)12(15)7-3-10-11(4-9(7)14)19-6-18-10/h3-5H,2,6H2,1H3,(H,16,17)
InChIKey
KYGZCKSPAKDVKC-UHFFFAOYSA-N
PubChem Compound ID
4628
PubChem Substance ID
13517, 409113, 590678, 597741, 855760, 5203902, 7849360, 7889637, 8149801, 8152840, 10321595, 11111565, 11111566, 11335834, 11361073, 11364291, 11366853, 11369415, 11372678, 11373764, 11377577, 11462045, 11466221, 11467341, 11484602, 11485802, 11488749, 11491305, 11491888, 11495211, 15197066, 17405510, 24278604, 25621581, 26612267, 26679848, 26747409, 26747410, 29223717, 47216777, 47588997, 47588998, 47736482, 47810754, 47810755, 47810756, 48035124, 48259230, 48414265, 48416363
Target and Pathway
Target(s) Vanilloid receptor 1 Target Info Antagonist [529807]
KEGG Pathway Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
NetPath Pathway IL2 Signaling Pathway
Pathway Interaction Database Trk receptor signaling mediated by the MAPK pathway
Trk receptor signaling mediated by PI3K and PLC-gamma
Reactome TRP channels
References
Ref 548350Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800024886)
Ref 529807GRC-6211, a new oral specific TRPV1 antagonist, decreases bladder overactivity and noxious bladder input in cystitis animal models. J Urol. 2009 Jan;181(1):379-86.

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