Drug Information

Drug General Information
Drug ID
D0E0GV
Former ID
DAP001507
Drug Name
Proquanil
Synonyms
Amepromat; Amosene; Anastress; Anathylmon; Anatimon; Andaksin; Andaxin; Aneural; Aneurol; Aneusral; Aneuxal; Aneuxral; Ansiatan; Ansietan; Ansil; Ansiowas; Anural; Anxietil; Anzil; Apascil; Apasil; Appetrol; Arcoban; Arpon; Artolon; Ataraxine; Atraxin; Auxietil; Ayeramate; Ayermate; Bamate; Biobamat; Biobamate; Brobamate; Calmadin; Calmax; Calmiren; Carbaxin; Cirpon; Cirponyl; Coprobate; Crestanil; Cypron; Cyrpon; Dapaz; Deprol; Despasmol; Dicandiol; Diron; Diurnal; Diurnaldiverondormabrol; Diveron; Dormabrol; Ecuanil; Edenal; Enorden; Epicur; Epikur; Equanil; Equatrate; Equilium; Equinil; Equitar; Erina; Estasil; Gadexyl; Gagexyl; Harmonin; Hartol; Holbamate; Ipsotian; Kessobamate; Klort; Larten; Lepenil; Lepetown; Letyl; Libiolan; Margonil; Mendel; Mepamtin; Mepantin; Mepavlon; Mepiosine; Meposed; Mepranil; Mepriam; Meprin; Meprindon; Meprobam; Meprobamat; Meprobamate; Meprobamato; Meprobamatum; Meproban; Meprocompren; Meprocon; Meprodil; Meprodiol; Meprol; Meproleaf; Meprosa; Meprosan; Meprosin; Meprospan; Meprotabs; Meprotan; Meprotanum; Meproten; Meprotil; Meprovan; Meprovanmeprozine; Meprozine; Meptran; Meptranactylmilprem; Metractyl; Metranquil; Micrainin; Milpath; Milprem; Miltamato; Miltann; Miltaun; Miltown; Miltuan; Miltwon; Misedant; Morbam; Multaun; Nephentine; Nervonus; Neuramate; Oasil; Optarket; Orlevol; Orolevol; Pancalma; Panediol; Pankalma; Pathibamate; Paxin; Pensive; Perequietil; Perequil; Perquietil; Pertranquil; Pimal; Placidon; Placitate; Prequil; Probamato; Probamyl; Probate; Procalmadiol; Procalmadol; Procalmidol; Procarbamide; Promate; Promato; Protran; Quaname; Quanane; Quanil; Quietidon; Quivet; Rastenil; Reostral; Restenil; Restenyl; Restinal; Restinil; Robamate;Sadanyl; Scolazil; Sedabamate; Sedanil; Sedanyl; Sedazil; Sedoquil; Sedoselecta; Selene; Seril; Setran; Shalvaton; Sowell; Spantran; Stensolo; Tamate; Tensol; Tensonal; Trancot; Trankvilan; Tranlisant; Tranmep; Tranquilan; Tranquilate; Tranquilax; Tranquiline; Tranquilsan; Tranquinol; Trelmar; Urbil; Urbilat; Vistabamate; Wardamate; Wyseals; Zirpon; Component of Appetrol; Component of Bamadex; Component of Equalysen; Component of Milpath; Component of Milprem; Component of Miltrate; Equanil suspension; Meprobamat [German]; Meprobamate and Aspirin Tablets; Meprobamato [Italian]; Meprobamic acid; Meprocon CMC; Solevione anastress; Bamd 400; Bamo 400; Canquil 400; Miltown 600; PMB 200; PMB 400; Apo-Meprobamate; Appetrol-Sr; Canquil-400; Component of PMB-400; Equanil (TN); Equazine-M; Fas-Cile; Fas-Cile 200; Kesso-Bamate; Mar-Bate; Meprin (VAN); Mepro-Aspirin; Mepro-analgesic; Meprobamato [INN-Spanish]; Meprobamatum [INN-Latin]; Meprospan-200; Meprospan-400; Milprem-200; Milprem-400; Miltown (TN); My-trans; Neo-Tran; PMB-200; PMB-400; Pan-tranquil; Q-Gesic; SK-Bamate; Tranquiline (Intra); Vio-Bamate; Cap-O-Tran; Carbamic acid 2-methyl-2-propyltrimethylene ester; Meprobamate (JAN/USP/INN); Meprobamate [USAN:INN:BAN:JAN]; Carbamic acid, 2-methyl-2-propyltrimethylene ester; [2-(carbamoyloxymethyl)-2-methylpentyl] carbamate; {2-[(carbamoyloxy)methyl]-2-methylpentyl} carbamate; 1,3-Propanediol, 2-methyl-2-propyl-, 1,3-dicarbamate; 1,3-Propanediol, 2-methyl-2-propyl-, dicarbamate; 2,2-Di(carbamoyloxymethyl)pentane; 2-Methyl-2-n-propyl-1,3-propanediol dicarbamate; 2-Methyl-2-propyl-1,3-propanediol dicarbamate; 2-Methyl-2-propylpropane-1,3-diol dicarbamate; 2-Methyl-2-propyltrimethylene carbamate; 2-Metil-2-n-propil-1,3-propanediol dicarbamato; 2-Metil-2-n-propil-1,3-propanediol dicarbamato [Spanish]; 2-[(carbamoyloxy)methyl]-2-methylpentyl carbamate; 3P Bamate
Drug Type
Small molecular drug
Indication Malaria; Anxiety disorder [ICD9: 300, 311; ICD10:B54, F32, F40-F42] Approved [536602], [551871]
Structure
Download
2D MOL

3D MOL
Formula
C9H18N2O4
Canonical SMILES
CCCC(C)(COC(=O)N)COC(=O)N
InChI
1S/C9H18N2O4/c1-3-4-9(2,5-14-7(10)12)6-15-8(11)13/h3-6H2,1-2H3,(H2,10,12)(H2,11,13)
InChIKey
NPPQSCRMBWNHMW-UHFFFAOYSA-N
CAS Number
CAS 57-53-4
PubChem Compound ID
4064
PubChem Substance ID
89640, 7366092, 7847442, 7979904, 8152550, 10527934, 14822610, 17389535, 24896728, 29223175, 46508142, 48416220, 48425274, 50021624, 50893943, 57654362, 68530538, 87245066, 103255535, 104305326, 108165187, 117425357, 124890349, 125353471, 126677741, 128736426, 134222669, 134337962, 134338694, 134338822, 134971019, 136949641, 137001618, 142043533, 144204614, 144207530, 144238911, 160963718, 164827462, 175268791, 176254515, 177513105, 178103799, 179225303, 184532185, 198991699, 223674399, 226405717, 249946527, 252403288
SuperDrug ATC ID
N05BC01
Target and Pathway
Target(s) Dihydrofolate reductase Target Info Inhibitor [536602]
PathWhiz Pathway Folate Metabolism
Pterine Biosynthesis
Reactome E2F mediated regulation of DNA replication
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Metabolism of folate and pterines
G1/S-Specific Transcription
References
Ref 536602The fight against drug-resistant malaria: novel plasmodial targets and antimalarial drugs. Curr Med Chem. 2008;15(2):161-71.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 536602The fight against drug-resistant malaria: novel plasmodial targets and antimalarial drugs. Curr Med Chem. 2008;15(2):161-71.

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