Target General Information
Target ID T08133
Target Name Transient receptor potential cation channel TrpV6
Synonyms CaT1; Calcium channel CAT1; Calcium transport protein CaT1; ECaC2; HTRP8; Transient receptor potential cation channel subfamily V, member 6; TRPV6
Target Type Clinical Trial
Gene Name TRPV6
Biochemical Class Transient receptor potential catioin channel
UniProt ID TRPV6_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease Ovarian cancer
Example drug SOR-C13 Phase 1 [523872], [1572592]
Tissue Ovarian tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: 3.02E-03
Z-score: 1.04E-02
P-value: 2.52E-01
Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section Fold-change: 0.15
Z-score: 0.41
P-value: 3.21E-01
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
Target gene expression profiles in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Reference
Ref 523872ClinicalTrials.gov (NCT01578564) Safety and Tolerability Study of SOR-C13 in Subjects With Advanced Cancers Commonly Known to Express the TRPV6 Channel. U.S. National Institutes of Health.
Ref 1572592NCBI GEO: archive for functional genomics data sets--update.

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