Target General Information
Target ID T22285
Target Name Glutamate NMDA receptor subunit epsilon 1
Synonyms HNR2A; N-methyl D-aspartate receptor subtype 2A; NMDA receptor NR2A; NMDAR2A; NR2A; GRIN2A
Target Type Successful
Gene Name GRIN2A
Biochemical Class Glutamate-gated ion channel
UniProt ID NMDE1_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease Parkinson's disease
Example drug NBQX Phase 1 [467600], [1572592]
Tissue Substantia nigra tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: -0.37
Z-score: -0.45
P-value: 8.43E-01
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Reference
Ref 467600(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4264).
Ref 1572592NCBI GEO: archive for functional genomics data sets--update.

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