Target expression details
Target General Information | |||||
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Target ID | T46781 | ||||
Target Name | Aurora kinase B | ||||
Synonyms | AIM-1; Aurora- and Ipl1-like midbody-associated protein 1; Aurora-2; Aurora-2 kinase; Aurora-B; Aurora-related kinase 2; Aurora/IPL1-related kinase 2; STK-1; Serine/threonine protein kinase 12; AURKB | ||||
Target Type | Clinical Trial | ||||
Gene Name | AURKB | ||||
Biochemical Class | Kinase | ||||
UniProt ID | AURKB_HUMAN | ||||
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals | |||||
Disease | Prostate cancer | ||||
Example drug | PHA-739358 | Phase 2 | [542852], [548410], [1572592] | ||
Tissue | Prostate | ||||
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: 0.20 Z-score: 0.86 P-value: 3.85E-05 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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Disease | Acute myelocytic leukemia | ||||
Example drug | BI-811283 | Phase 1 | [522353], [1572592] | ||
Tissue | Bone marrow | ||||
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: -0.82 Z-score: -1.62 P-value: 3.52E-36 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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Target Gene Expression Profiles in Other Tissues of Healthy Individuals | |||||
Reference | |||||
Ref 548410 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025382) | ||||
Ref 542852 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7937). |
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