Target expression details
| Target General Information | |||||
|---|---|---|---|---|---|
| Target ID | T51487 | ||||
| Target Name | GABA(A) receptor alpha-1 | ||||
| Synonyms | GABA(A) receptor subunit alpha-1; GABRA1 | ||||
| Target Type | Successful | ||||
| Gene Name | GABRA1 | ||||
| Biochemical Class | Ligand-gated ion channel | ||||
| UniProt ID | GBRA1_HUMAN | ||||
| Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals | |||||
| Disease | Depression | ||||
| Example drug | Barbituric acid | Approved | [1], [2] | ||
| Tissue | Pre-frontal cortex | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: -0.12 Z-score: -0.18 P-value: 9.57E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Disease | Epilepsy | ||||
| Example drug | Nitrazepam | Approved | [3], [4], [2] | ||
| Tissue | Peritumoral cortex tissue | ||||
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of the persons with other diseases not directly affecting the tissue
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| Target Gene Expression Profiles in Other Tissues of Healthy Individuals | |||||
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| Reference | |||||
| REF 1 | DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6. Epub 2007 Nov 29. | ||||
| REF 2 | NCBI GEO: archive for functional genomics data sets--update. | ||||
| REF 3 | Drug information of Nitrazepam, 2008. eduDrugs. | ||||
| REF 4 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | ||||
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