Target General Information
Target ID T55922
Target Name S-adenosylmethioninedecarboxylase proenzyme
Synonyms AdoMetDC; S-adenosylmethioninedecarboxylase; SamDC; AMD1
Target Type Clinical Trial
Gene Name AMD1
Biochemical Class Carbon-carbon lyase
UniProt ID DCAM_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease Head and neck cancer
Example drug MGBG Terminated [525957], [535793], [1572592]
Tissue Head and neck tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: 0.37
Z-score: 0.61
P-value: 4.41E-05
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Reference
Ref 525957Spermine deficiency resulting from targeted disruption of the spermine synthase gene in embryonic stem cells leads to enhanced sensitivity to antiproliferative drugs. Mol Pharmacol. 2001 Feb;59(2):231-8.
Ref 535793S-adenosylmethionine decarboxylase as an enzyme target for therapy. Pharmacol Ther. 1992 Dec;56(3):359-77.
Ref 1572592NCBI GEO: archive for functional genomics data sets--update.

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