Target expression details
Target General Information | |||||
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Target ID | T55922 | ||||
Target Name | S-adenosylmethioninedecarboxylase proenzyme | ||||
Synonyms | AdoMetDC; S-adenosylmethioninedecarboxylase; SamDC; AMD1 | ||||
Target Type | Clinical Trial | ||||
Gene Name | AMD1 | ||||
Biochemical Class | Carbon-carbon lyase | ||||
UniProt ID | DCAM_HUMAN | ||||
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals | |||||
Disease | Head and neck cancer | ||||
Example drug | MGBG | Terminated | [525957], [535793], [1572592] | ||
Tissue | Head and neck tissue | ||||
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: 0.37 Z-score: 0.61 P-value: 4.41E-05 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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Target Gene Expression Profiles in Other Tissues of Healthy Individuals | |||||
Reference | |||||
Ref 525957 | Spermine deficiency resulting from targeted disruption of the spermine synthase gene in embryonic stem cells leads to enhanced sensitivity to antiproliferative drugs. Mol Pharmacol. 2001 Feb;59(2):231-8. |
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