Target expression details
Target General Information | |||||
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Target ID | T56365 | ||||
Target Name | Differentiation antigen CD19 | ||||
Synonyms | B-lymphocyte surface antigen B4; Differentiation antigen CD19; Leu-12; CD19 | ||||
Target Type | Clinical Trial | ||||
Gene Name | CD19 | ||||
Biochemical Class | Immunoglobulin | ||||
UniProt ID | CD19_HUMAN | ||||
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals | |||||
Disease | Acute myelocytic leukemia | ||||
Example drug | MDX-1342 | Phase 2 | [524501], [1572592] | ||
Tissue | Bone marrow | ||||
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: -1.06 Z-score: -1.33 P-value: 2.33E-24 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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Disease | Myeloma | ||||
Example drug | MEDI-551 | Phase 1 | [542906], [551134], [1572592] | ||
Tissue | Bone marrow | ||||
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: -1.90 Z-score: -6.64 P-value: 2.33E-07 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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Target Gene Expression Profiles in Other Tissues of Healthy Individuals | |||||
Reference | |||||
Ref 542906 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7992). |
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