Target General Information
Target ID T59604
Target Name Growth hormone secretagogue receptor type 1
Synonyms GH-releasing peptide receptor; GHRP; GHS-R; Ghrelin receptor; Growth hormone secretagogue receptor; GHSR
Target Type Successful
Gene Name GHSR
Biochemical Class GPCR rhodopsin
UniProt ID GHSR_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease Type 2 diabetes
Example drug PF-05190457 Phase 1 [523786], [1572592]
Tissue Liver tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: -0.14
Z-score: -0.74
P-value: 4.56E-01
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Disease Eosinophilic gastritis
Tissue Gastric antrum tissue
Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section Fold-change: 0.34
Z-score: 2.10
P-value: 4.45E-02
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Reference
Ref
Ref 523786ClinicalTrials.gov (NCT01522807) A Study Of Three PF-05190457 Formulations In Healthy Volunteers. U.S. National Institutes of Health.
Ref 1572592NCBI GEO: archive for functional genomics data sets--update.

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