Target General Information
Target ID T62184
Target Name Sodium- and chloride-dependent GABA transporter 1
Synonyms GABA transporter 1; SLC6A1
Target Type Successful
Gene Name SLC6A1
Biochemical Class Neurotransmitter:sodium symporter
UniProt ID SC6A1_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease Myeloma
Example drug Metadoxine Approved [524626], [531706], [1572592]
Tissue Bone marrow
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: -0.24
Z-score: -0.62
P-value: 4.99E-02
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Reference
Ref 531706Preliminary findings on the use of metadoxine for the treatment of alcohol dependence and alcoholic liver disease. Hum Psychopharmacol. 2011 Dec;26(8):554-9.
Ref 524626ClinicalTrials.gov (NCT02051842) Effect of Metadoxine on Oxidative Stress in Non-alcoholic Hepatic Steatosis. U.S. National Institutes of Health.
Ref 1572592NCBI GEO: archive for functional genomics data sets--update.

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