Target General Information
Target ID	T62193
Target Name	Aromatic-L-amino-acid decarboxylase
Synonyms	AADC; DOPA decarboxylase; DDC
Target Type	Successful
Gene Name	DDC
Biochemical Class	Carbon-carbon lyase
UniProt ID	DDC_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease	Parkinson's disease
Example drug	Carbidopa			Approved	[468222], [536121], [1572592]
Tissue	Substantia nigra tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: -1.49 Z-score: -1.01 P-value: 7.84E-03
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Download the Expression Profile (Genomics. 86(2):127-41, 2005)
Reference
Ref 468222	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5159).
Ref 536121	Emerging drugs for restless legs syndrome. Expert Opin Emerg Drugs. 2005 Aug;10(3):537-52.
Ref 1572592	NCBI GEO: archive for functional genomics data sets--update.

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