Target expression details
Target General Information | |||||
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Target ID | T63484 | ||||
Target Name | Glucose-6-phosphate dehydrogenase | ||||
Synonyms | G6PD | ||||
Target Type | Clinical Trial | ||||
Gene Name | G6PD | ||||
Biochemical Class | Short-chain dehydrogenases reductases | ||||
UniProt ID | G6PD_HUMAN | ||||
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals | |||||
Disease | Chronic obstructive pulmonary disease | ||||
Example drug | Prasterone | Phase 3 | [527619], [1572592] | ||
Tissue | Small airway epithelium | ||||
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: 0.44 Z-score: 0.60 P-value: 2.39E-03 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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Disease | Chronic obstructive pulmonary disease | ||||
Example drug | Prasterone | Phase 3 | [527619], [1572592] | ||
Tissue | Lung tissue | ||||
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: -0.18 Z-score: -0.30 P-value: 4.01E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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Disease | Rheumatoid arthritis | ||||
Example drug | CBF-BS2 | Discontinued in Phase 2 | [546290], [1572592] | ||
Tissue | Synovial tissue | ||||
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: 2.13 Z-score: 4.86 P-value: 7.05E-07 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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Target Gene Expression Profiles in Other Tissues of Healthy Individuals | |||||
Reference | |||||
Ref 546290 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007279) |
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