Target expression details

Target General Information
Target ID T76414
Target Name Glutamate NMDA receptor subunit epsilon 2
Synonyms Glutamate receptor NR2B subunit; HNR3; N-methyl-D-aspartate receptor subunit 3; N-methylD-aspartate receptor subtype 2B; NMDA NR2B receptor; NMDA receptor NR2B; NMDA receptor subunit 2B; NMDAR2B; NR2B; NR3; GRIN2B
Target Type Clinical Trial
Gene Name GRIN2B
Biochemical Class Glutamate-gated ion channel
UniProt ID NMDE2_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease Depression
Example drug CERC-301 Phase 2 [525218], [1572592]
Tissue Pre-frontal cortex
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: 0.14
Z-score: 0.29
P-value: 1.23E-01
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Download target gene expression data of the patients in the disease section of the tissue
Download target gene expression data in the tissue of healthy individual
Disease Multiple sclerosis
Example drug ELIPRODIL Phase 2 [521427], [1572592]
Tissue Spinal cord
Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section Fold-change: 0.01
Z-score: 0.27
P-value: 6.76E-01
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
Download target gene expression data of the patients in the disease section of the tissue
Download target gene expression data of the patients in the normal section of the tissue adjacent to the disease section
Disease Parkinson's disease
Example drug CP-101,606 Phase 2 [521577], [1572592]
Tissue Substantia nigra tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: -0.06
Z-score: -0.32
P-value: 7.51E-01
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Download target gene expression data of the patients in the disease section of the tissue
Download target gene expression data in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Download the Expression Profile (Genomics. 86(2):127-41, 2005)
Reference
Ref 521427ClinicalTrials.gov (NCT00001929) Treatment of Parkinson's Disease With Eliprodil. U.S. National Institutes of Health.
Ref 521577ClinicalTrials.gov (NCT00073476) A Study to Evaluate the Efficacy and Safety of CP-101,606 in Subjects With an Acute Stroke. U.S. National Institutes of Health.
Ref 525218ClinicalTrials.gov (NCT02459236) A Study of Intermittent Doses of CERC-301 in MDD.
Ref 1572592NCBI GEO: archive for functional genomics data sets--update.

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