Target Information
Target General Infomation | |||||
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Target ID |
T03755
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Former ID |
TTDC00244
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Target Name |
Bcl-2-like protein 2
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Gene Name |
BCL2L2
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Synonyms |
Apoptosis regulator Bcl-W; Bcl2-L-2; BCL2L2
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Target Type |
Clinical Trial
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Disease | Advanced small cell lung cancer; Relapsed or refractory chronic lymphocytic leukemia; Lymphoid malignancies [ICD9: 140-229, 140-239, 162, 162.9, 202, 204.0, 204.1, 208.9; ICD10: C33-C34, C34.90, C81-C86, C91-C95, C91.0, C91.1] | ||||
Function |
Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.
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BioChemical Class |
Bcl-2 family
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Target Validation |
T03755
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UniProt ID | |||||
Sequence |
MATPASAPDTRALVADFVGYKLRQKGYVCGAGPGEGPAADPLHQAMRAAGDEFETRFRRT
FSDLAAQLHVTPGSAQQRFTQVSDELFQGGPNWGRLVAFFVFGAALCAESVNKEMEPLVG QVQEWMVAYLETQLADWIHSSGGWAEFTALYGDGALEEARRLREGNWASVRTVLTGAVAL GALVTVGAFFASK |
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Drugs and Mode of Action | |||||
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM) | |||||
TEP | EXP Info | ||||
Pathways | |||||
KEGG Pathway | MicroRNAs in cancer | ||||
PANTHER Pathway | Apoptosis signaling pathway | ||||
Pathway Interaction Database | Direct p53 effectors | ||||
WikiPathways | Apoptosis | ||||
Apoptosis Modulation and Signaling | |||||
References |
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