Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T05387
|
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| Former ID |
TTDC00120
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| Target Name |
Protein-glutamine gamma-glutamyltransferase
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| Gene Name |
TGM2
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| Synonyms |
TG(C); TG(C)Protein-glutamine gamma-glutamyltransferase; TGC; TGase C; TGase-H; TTg; Tissue transglutaminase; Tranglutaminase 2; Transglutaminase 2; TGM2
|
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| Target Type |
Research
|
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| Function |
Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.
|
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| BioChemical Class |
Acyltransferase
|
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| Target Validation |
T05387
|
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| UniProt ID | |||||
| EC Number |
EC 2.3.2.13
|
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| Sequence |
MAEELVLERCDLELETNGRDHHTADLCREKLVVRRGQPFWLTLHFEGRNYEASVDSLTFS
VVTGPAPSQEAGTKARFPLRDAVEEGDWTATVVDQQDCTLSLQLTTPANAPIGLYRLSLE ASTGYQGSSFVLGHFILLFNAWCPADAVYLDSEEERQEYVLTQQGFIYQGSAKFIKNIPW NFGQFEDGILDICLILLDVNPKFLKNAGRDCSRRSSPVYVGRVVSGMVNCNDDQGVLLGR WDNNYGDGVSPMSWIGSVDILRRWKNHGCQRVKYGQCWVFAAVACTVLRCLGIPTRVVTN YNSAHDQNSNLLIEYFRNEFGEIQGDKSEMIWNFHCWVESWMTRPDLQPGYEGWQALDPT PQEKSEGTYCCGPVPVRAIKEGDLSTKYDAPFVFAEVNADVVDWIQQDDGSVHKSINRSL IVGLKISTKSVGRDEREDITHTYKYPEGSSEEREAFTRANHLNKLAEKEETGMAMRIRVG QSMNMGSDFDVFAHITNNTAEEYVCRLLLCARTVSYNGILGPECGTKYLLNLNLEPFSEK SVPLCILYEKYRDCLTESNLIKVRALLVEPVINSYLLAERDLYLENPEIKIRILGEPKQK RKLVAEVSLQNPLPVALEGCTFTVEGAGLTEEQKTVEIPDPVEAGEEVKVRMDLLPLHMG LHKLVVNFESDKLKAVKGFRNVIIGPA |
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| Structure |
1FAU; 1KV3; 2Q3Z; 3LY6; 3S3J; 3S3P; 3S3S
|
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| Inhibitor | Guanosine-5'-Diphosphate | Drug Info | [1] | ||
| Pathways | |||||
| KEGG Pathway | Huntington' | ||||
| s disease | |||||
| Pathway Interaction Database | Beta1 integrin cell surface interactions | ||||
| Thromboxane A2 receptor signaling | |||||
| Alpha9 beta1 integrin signaling events | |||||
| References | |||||
| REF 1 | How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. | ||||
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