Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T05387
|
||||
| Former ID |
TTDC00120
|
||||
| Target Name |
Protein-glutamine gamma-glutamyltransferase
|
||||
| Gene Name |
TGM2
|
||||
| Synonyms |
TG(C); TG(C)Protein-glutamine gamma-glutamyltransferase; TGC; TGase C; TGase-H; TTg; Tissue transglutaminase; Tranglutaminase 2; Transglutaminase 2; TGM2
|
||||
| Target Type |
Research
|
||||
| Function |
Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.
|
||||
| BioChemical Class |
Acyltransferase
|
||||
| Target Validation |
T05387
|
||||
| UniProt ID | |||||
| EC Number |
EC 2.3.2.13
|
||||
| Sequence |
MAEELVLERCDLELETNGRDHHTADLCREKLVVRRGQPFWLTLHFEGRNYEASVDSLTFS
VVTGPAPSQEAGTKARFPLRDAVEEGDWTATVVDQQDCTLSLQLTTPANAPIGLYRLSLE ASTGYQGSSFVLGHFILLFNAWCPADAVYLDSEEERQEYVLTQQGFIYQGSAKFIKNIPW NFGQFEDGILDICLILLDVNPKFLKNAGRDCSRRSSPVYVGRVVSGMVNCNDDQGVLLGR WDNNYGDGVSPMSWIGSVDILRRWKNHGCQRVKYGQCWVFAAVACTVLRCLGIPTRVVTN YNSAHDQNSNLLIEYFRNEFGEIQGDKSEMIWNFHCWVESWMTRPDLQPGYEGWQALDPT PQEKSEGTYCCGPVPVRAIKEGDLSTKYDAPFVFAEVNADVVDWIQQDDGSVHKSINRSL IVGLKISTKSVGRDEREDITHTYKYPEGSSEEREAFTRANHLNKLAEKEETGMAMRIRVG QSMNMGSDFDVFAHITNNTAEEYVCRLLLCARTVSYNGILGPECGTKYLLNLNLEPFSEK SVPLCILYEKYRDCLTESNLIKVRALLVEPVINSYLLAERDLYLENPEIKIRILGEPKQK RKLVAEVSLQNPLPVALEGCTFTVEGAGLTEEQKTVEIPDPVEAGEEVKVRMDLLPLHMG LHKLVVNFESDKLKAVKGFRNVIIGPA |
||||
| Structure |
1FAU; 1KV3; 2Q3Z; 3LY6; 3S3J; 3S3P; 3S3S
|
||||
| Pathways | |||||
| KEGG Pathway | Huntington' | ||||
| s disease | |||||
| Pathway Interaction Database | Beta1 integrin cell surface interactions | ||||
| Thromboxane A2 receptor signaling | |||||
| Alpha9 beta1 integrin signaling events | |||||
| References | |||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.