Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T08378
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| Former ID |
TTDS00513
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| Target Name |
Sodium-dependent vitamin C transporter 2
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| Gene Name |
SLC23A2
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| Synonyms |
KIAA0238; NBTL1; Na(+)/L-ascorbic acid transporter 2; Nucleobase transporter-like 1 protein; SLC23A1; SVCT2; Solute carrier family 23 member 2; YSPL2; Yolksac permease-like molecule 2; hSVCT2; SLC23A2
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| Target Type |
Successful
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| Disease | Primary biliary cirrhosis [ICD9: 571.6; ICD10: K74.3] | ||||
| Function |
Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate.
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| BioChemical Class |
Nucleobase ascorbate transporter
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| UniProt ID | |||||
| Sequence |
MMGIGKNTTSKSMEAGSSTEGKYEDEAKHPAFFTLPVVINGGATSSGEQDNEDTELMAIY
TTENGIAEKSSLAETLDSTGSLDPQRSDMIYTIEDVPPWYLCIFLGLQHYLTCFSGTIAV PFLLADAMCVGYDQWATSQLIGTIFFCVGITTLLQTTFGCRLPLFQASAFAFLAPARAIL SLDKWKCNTTDVSVANGTAELLHTEHIWYPRIREIQGAIIMSSLIEVVIGLLGLPGALLK YIGPLTITPTVALIGLSGFQAAGERAGKHWGIAMLTIFLVLLFSQYARNVKFPLPIYKSK KGWTAYKLQLFKMFPIILAILVSWLLCFIFTVTDVFPPDSTKYGFYARTDARQGVLLVAP WFKVPYPFQWGLPTVSAAGVIGMLSAVVASIIESIGDYYACARLSCAPPPPIHAINRGIF VEGLSCVLDGIFGTGNGSTSSSPNIGVLGITKVGSRRVIQCGAALMLALGMIGKFSALFA SLPDPVLGALFCTLFGMITAVGLSNLQFIDLNSSRNLFVLGFSIFFGLVLPSYLRQNPLV TGITGIDQVLNVLLTTAMFVGGCVAFILDNTIPGTPEERGIRKWKKGVGKGNKSLDGMES YNLPFGMNIIKKYRCFSYLPISPTFVGYTWKGLRKSDNSRSSDEDSQATG |
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| Drugs and Mode of Action | |||||
| Drug(s) | Ursodeoxycholic acid | Drug Info | Approved | Primary biliary cirrhosis | [1], [2] |
| Activator | Ursodeoxycholic acid | Drug Info | [3], [4] | ||
| Modulator | [14C]ascorbic acid | Drug Info | [5] | ||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7104). | ||||
| REF 2 | Drug information of Ursodeoxycholic acid, 2008. eduDrugs. | ||||
| REF 3 | Influence of ursodeoxycholic acid on the mortality and malignancy associated with primary biliary cirrhosis: a population-based cohort study. Hepatology. 2007 Oct;46(4):1131-7. | ||||
| REF 4 | Role of vitamin C transporters and biliverdin reductase in the dual pro-oxidant and anti-oxidant effect of biliary compounds on the placental-fetal unit in cholestasis during pregnancy. Toxicol Appl Pharmacol. 2008 Oct 15;232(2):327-36. Epub 2008 Jul 23. | ||||
| REF 5 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1042). | ||||
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