Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T22976
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| Former ID |
TTDR00783
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| Target Name |
Deoxyribonucleoside phosphotransferase
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| Gene Name |
dnk
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| Synonyms |
Deoxyribonucleoside kinase; Dm-Dnk; Multispecific deoxynucleoside kinase; dnk
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| Target Type |
Research
|
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| Function |
Deoxyribonucleoside kinase that has a broad specificity phosphorylating thymidine, deoxyadenosine, deoxycytidine and deoxyguanosine. Specificity is higher for pyrimidine nucleosides. Several anti-viral and anti-cancer nucleoside analogs are also efficiently phosphorylated.
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| BioChemical Class |
Kinase
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| Target Validation |
T22976
|
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| UniProt ID | |||||
| EC Number |
EC 2.7.1.145
|
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| Sequence |
MAEAASCARKGTKYAEGTQPFTVLIEGNIGSGKTTYLNHFEKYKNDICLLTEPVEKWRNV
NGVNLLELMYKDPKKWAMPFQSYVTLTMLQSHTAPTNKKLKIMERSIFSARYCFVENMRR NGSLEQGMYNTLEEWYKFIEESIHVQADLIIYLRTSPEVAYERIRQRARSEESCVPLKYL QELHELHEDWLIHQRRPQSCKVLVLDADLNLENIGTEYQRSESSIFDAISSNQQPSPVLV SPSKRQRVAR |
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| Inhibitor | 1-[(Z)-4-(triphenylmethoxy)-2-butenyl]thymine | Drug Info | [1] | ||
| 1-[5-(triphenylmethoxy)pentyl]thymine | Drug Info | [1] | |||
| 1-[6-(triphenylmethoxy)hexyl]thymine | Drug Info | [1] | |||
| References | |||||
| REF 1 | J Med Chem. 2006 Dec 28;49(26):7766-73.N1-substituted thymine derivatives as mitochondrial thymidine kinase (TK-2) inhibitors. | ||||
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