Target Information

Target General Infomation
Target ID
T22976
Former ID
TTDR00783
Target Name
Deoxyribonucleoside phosphotransferase
Gene Name
dnk
Synonyms
Deoxyribonucleoside kinase; Dm-Dnk; Multispecific deoxynucleoside kinase; dnk
Target Type
Research
Function
Deoxyribonucleoside kinase that has a broad specificity phosphorylating thymidine, deoxyadenosine, deoxycytidine and deoxyguanosine. Specificity is higher for pyrimidine nucleosides. Several anti-viral and anti-cancer nucleoside analogs are also efficiently phosphorylated.
BioChemical Class
Kinase
Target Validation
T22976
UniProt ID
Q9XZT6
EC Number
EC 2.7.1.145
Sequence
MAEAASCARKGTKYAEGTQPFTVLIEGNIGSGKTTYLNHFEKYKNDICLLTEPVEKWRNV
NGVNLLELMYKDPKKWAMPFQSYVTLTMLQSHTAPTNKKLKIMERSIFSARYCFVENMRR
NGSLEQGMYNTLEEWYKFIEESIHVQADLIIYLRTSPEVAYERIRQRARSEESCVPLKYL
QELHELHEDWLIHQRRPQSCKVLVLDADLNLENIGTEYQRSESSIFDAISSNQQPSPVLV
SPSKRQRVAR
Inhibitor 1-[(Z)-4-(triphenylmethoxy)-2-butenyl]thymine Drug Info [528583]
1-[5-(triphenylmethoxy)pentyl]thymine Drug Info [528583]
1-[6-(triphenylmethoxy)hexyl]thymine Drug Info [528583]
References
Ref 528583J Med Chem. 2006 Dec 28;49(26):7766-73.N1-substituted thymine derivatives as mitochondrial thymidine kinase (TK-2) inhibitors.

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