Target Information
Target General Infomation | |||||
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Target ID |
T43721
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Former ID |
TTDR01269
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Target Name |
Corticosteroid 11-beta-dehydrogenase, isozyme 2
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Gene Name |
HSD11B2
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Synonyms |
11 beta-HSD2; 11 beta-hydroxysteroid dehydrogenase type 2; 11-DH2; 11-beta-HSD2; 11-beta-hydroxysteroid dehydrogenase type 2; NAD-dependent 11-beta-hydroxysteroid dehydrogenase; HSD11B2
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Target Type |
Clinical Trial
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Disease | Type 2 diabetes [ICD9: 250; ICD10: E11] | ||||
Function |
Catalyzes the conversion of cortisol to the inactive metabolite cortisone. modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids.
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BioChemical Class |
Short-chain dehydrogenases reductases
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Target Validation |
T43721
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UniProt ID | |||||
EC Number |
EC 1.1.1.-
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Sequence |
MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAV
LAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPG AIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELS PVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVA LLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYI EHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRR RFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR |
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Drugs and Mode of Action | |||||
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM) | |||||
TEP | EXP Info | ||||
Pathways | |||||
KEGG Pathway | Steroid hormone biosynthesis | ||||
Aldosterone-regulated sodium reabsorption | |||||
NetPath Pathway | EGFR1 Signaling Pathway | ||||
PathWhiz Pathway | Steroidogenesis | ||||
Reactome | Glucocorticoid biosynthesis | ||||
WikiPathways | Prostaglandin Synthesis and Regulation | ||||
Glucocorticoid & | |||||
Mineralcorticoid Metabolism | |||||
References | |||||
Ref 530656 | Bioorg Med Chem. 2010 Feb 15;18(4):1507-15. Epub 2010 Jan 11.11beta-Hydroxysteroid dehydrogenase 1 inhibiting constituents from Eriobotrya japonica revealed by bioactivity-guided isolation and computational approaches. |
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