Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T44516
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| Former ID |
TTDR00071
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| Target Name |
Potassium voltage-gated channel subfamily B member 1
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| Gene Name |
KCNB1
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| Synonyms |
H-DRK1; Potassium channel Kv2.1; Rectifier potassium channel Kv2.1; Voltage-gated potassium channel subunit Kv2.1; KCNB1
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| Target Type |
Research
|
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| Function |
Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient.
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| BioChemical Class |
Voltage-gated ion channel
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| UniProt ID | |||||
| Sequence |
MPAGMTKHGSRSTSSLPPEPMEIVRSKACSRRVRLNVGGLAHEVLWRTLDRLPRTRLGKL
RDCNTHDSLLEVCDDYSLDDNEYFFDRHPGAFTSILNFYRTGRLHMMEEMCALSFSQELD YWGIDEIYLESCCQARYHQKKEQMNEELKREAETLREREGEEFDNTCCAEKRKKLWDLLE KPNSSVAAKILAIISIMFIVLSTIALSLNTLPELQSLDEFGQSTDNPQLAHVEAVCIAWF TMEYLLRFLSSPKKWKFFKGPLNAIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFR IMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDDTK FKSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFY KEQKRQEKAIKRREALERAKRNGSIVSMNMKDAFARSIEMMDIVVEKNGENMGKKDKVQD NHLSPNKWKWTKRTLSETSSSKSFETKEQGSPEKARSSSSPQHLNVQQLEDMYNKMAKTQ SQPILNTKESAAQSKPKEELEMESIPSPVAPLPTRTEGVIDMRSMSSIDSFISCATDFPE ATRFSHSPLTSLPSKTGGSTAPEVGWRGALGASGGRFVEANPSPDASQHSSFFIESPKSS MKTNNPLKLRALKVNFMEGDPSPLLPVLGMYHDPLRNRGSAAAAVAGLECATLLDKAVLS PESSIYTTASAKTPPRSPEKHTAIAFNFEAGVHQYIDADTDDEGQLLYSVDSSPPKSLPG STSPKFSTGTRSEKNHFESSPLPTSPKFLRQNCIYSTEALTGKGPSGQEKCKLENHISPD VRVLPGGGAHGSTRDQSI |
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| Blocker (channel blocker) | 3-bicyclo[2.2.1]hept-2-yl-benzene-1,2-diol | Drug Info | [1] | ||
| DABCO-C16 | Drug Info | [2] | |||
| tetraethylammonium | Drug Info | [3] | |||
| Inhibitor (gating inhibitor) | RY796 | Drug Info | [4] | ||
| Pathways | |||||
| Reactome | Voltage gated Potassium channels | ||||
| Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | |||||
| WikiPathways | Calcium Regulation in the Cardiac Cell | ||||
| Potassium Channels | |||||
| References | |||||
| REF 1 | Novel neuroprotective K+ channel inhibitor identified by high-throughput screening in yeast. Mol Pharmacol. 2004 Jan;65(1):214-9. | ||||
| REF 2 | 1,4-Diazabicyclo[2.2.2]octane derivatives: a novel class of voltage-gated potassium channel blockers. Mol Pharmacol. 2006 Mar;69(3):718-26. Epub 2005 Nov 29. | ||||
| REF 3 | Modulation of Kv2.1 channel gating and TEA sensitivity by distinct domains of SNAP-25. Biochem J. 2006 Jun 1;396(2):363-9. | ||||
| REF 4 | Identification of novel and selective Kv2 channel inhibitors. Mol Pharmacol. 2011 Dec;80(6):959-64. | ||||
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